WebMar 5, 2011 · Moreover, HE staining of the colon sections revealed that the inflammation of the colon tissue was more severe in the AhR KO mice than in the C57BL/6J WT mice (Fig. 1c), and the histological scores for the colon tissue of the 2 and 3% DSS-treated AhR KO mice were significantly higher than those of the C57BL/6J WT mice (Fig. 1d). WebJan 1, 2024 · Supernatant of colon cancer cells was used to culture activated T cells and mice spleen lymphocytes, and the IDO1-Kyn-aryl hydrocarbon (AhR) receptor axis was determined in vitro. In vivo, an (AOM)/dextran (DSS)–induced CRC model was established in IDO–/–, Rag1, and wild-type mice, and tumor-associated T and Kyn/AhR Results
Loss of Aryl Hydrocarbon Receptor Promotes Colon …
WebFeb 8, 2024 · Aryl Hydrocarbon Receptor (AhR) Signaling in Colonic Cells and Tumors 1. Introduction:. The aryl hydrocarbon receptor (AhR) is a basic helix-loop-helix protein that … WebAug 18, 2024 · Coffee extracts also enhanced overall formation of AhR-active microbial metabolites. Conclusions. In colon-derived cells and in the mouse intestine, coffee induced several AhR-dependent responses including gene expression, inhibition of intestinal stem cell-enriched organoid growth, and inhibition of DSS-induced intestinal barrier damage. teerapat rattanakarn
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WebOct 29, 2015 · KGF Activated AhR Regulates Colon Cancer Cell Growth. To examine the role of AhR in KGF-induced colon cancer cell growth, siRNA was used to knock down the expression of AhR. In Fig. 4a, the effect of siAhR was detected using western blot analysis and the results showed that AhR was significantly knocked down in LoVo cells and T84 … WebAug 17, 2024 · (A) Representative images of AB-PAS staining (goblet cells) in distal colon of Ahr −/− mice treated with vehicle or ICA for 2 wk. (B) Quantitation of goblet cells per crypt in Ahr −/− mice or WT littermates. (C) Average colon crypt length of WT and Ahr −/− mice. tee ranurada 2 1/2