WebChloramphenicol-Acetyltransferase (oder CAT) ist ein bakterielles Enzym (EC 2.3.1.28). Es acetyliert das Antibiotikum Chloramphenicol unter Verbrauch von Acetyl-CoA an zwei Stellen. Da acetyliertes Chloramphenicol nicht mehr an Ribosomen bindet und damit nicht mehr die Translation hemmen kann, vermittelt das Gen eine Resistenz gegen dieses … WebChloramphenicol Drug Class: Antibiotic (broad spectrum & bacteriostatic) Mechanism of Action: binds to specific nucleotides within the 50S ribosome, which inhibits peptidyl transferase activity & peptide bond formation (Lambert, 2012) chloramphenicol can inhibit both bacterial and mitochondrial ribosomes (but not cytoplasmic).
What type of antimicrobial agent is chloramphenicol? - Answers
Webכלורמפניקול (באנגלית: Chloramphenicol) היא תרופה אנטיביוטית בקטריוסטטית. בישראל היא מוכרת בעיקר בשמות המסחריים סינטומיצין, תרוצידין ותריאולון.מקורה בחיידק Streptomyces venezuelae.התרופה בודדה לראשונה על ידי דייוויד גוטליב. Chloramphenicol is an antibiotic useful for the treatment of a number of bacterial infections. This includes use as an eye ointment to treat conjunctivitis. By mouth or by injection into a vein, it is used to treat meningitis, plague, cholera, and typhoid fever. Its use by mouth or by injection is only recommended when … See more The original indication of chloramphenicol was in the treatment of typhoid, but the presence of multiple drug-resistant Salmonella Typhi has meant it is seldom used for this indication except when the organism is known … See more Chloramphenicol is extremely lipid-soluble; it remains relatively unbound to protein and is a small molecule. It has a large apparent volume of distribution and penetrates … See more Chloramphenicol was first isolated from Streptomyces venezuelae in 1947 and in 1949 a team of scientists at Parke-Davis including Mildred Rebstock published their identification of the chemical structure and their synthesis. In 1972, Senator See more Although its use in veterinary medicine is highly restricted, chloramphenicol still has some important veterinary uses. It is currently … See more Aplastic anemia The most serious side effect of chloramphenicol treatment is aplastic anaemia. … See more Chloramphenicol is a bacteriostatic agent, inhibiting protein synthesis. It prevents protein chain elongation by inhibiting the peptidyl transferase activity of the bacterial ribosome. It specifically binds to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal … See more Names Chloramphenicol is available as a generic worldwide under many brandnames and also under various … See more memorial day business closed sign
File:Chloramphenicol.svg - Wikimedia Commons - Wikipedia
Webchloramphenicol: ChEBI ID CHEBI:17698: Definition An organochlorine compound that is dichloro-substituted acetamide containing a nitrobenzene ring, an amide bond and two alcohol functions. Stars This entity has been manually annotated by the ChEBI Team. ... WebMedia in category "Chloramphenicol" The following 24 files are in this category, out of 24 total. Chloramphenicol acetyltransferase 3CLA transparent.png 1,000 × 996; 513 KB. … WebChloramphenicol prevents protein chain elongation by inhibiting the peptidyl transferase activity of the bacterial ribosome. It specifically binds to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal … memorial day bus tours in wash dc