2024 Klf4 chip

Klf4 chip

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August undefined, 2024

WebMar 7, 2013 · The ChIP-seq data at the Klf4 gene locus revealed a distal region with multiple IRF8 ChIP-seq peaks spanning 120 kb (208 to 328 kb upstream of the Klf4 TSS) (Figure 3A and supplemental Figure 2). Each IRF8 ChIP-seq peak contained composite elements for IRF and ETS. Importantly, this region was tightly associated with high levels of the H3K4me1 ... WebMar 21, 2024 · KLF4 (KLF Transcription Factor 4) is a Protein Coding gene. Diseases associated with KLF4 include Epilepsy, Idiopathic Generalized 15 and Familial Adenomatous Polyposis . Among its related pathways are …

Prognostic significance of KLF4 in solid tumours: an updated …

http://homer.ucsd.edu/homer/workshops/170209-MED263/index.html WebKLF4 belongs to the KLF family of transcription factors that regulate several cell functions. It is highly expressed in differentiated epithelial cells of the … pens knitting lady wsj

Mouse KLF4 Antibody AF3158: R&D Systems

WebFeb 28, 2024 · GEO help: Mouse over screen elements for information. ChIP-nexus data for Oct4, Sox2, Nanog and Klf4 in mouse embryonic stem cells. The goal of this study was discover the transcription binding synthax for the key differentiation TFs in mouse embryonic stem cells. Genes are regulated through enhancer sequences, in which … WebMay 4, 2024 · Furthermore, ChIP showed that KLF4 protein could bind to the TERT promoter region in MLE-12 cells, suggesting that KLF4 could implicate in pathogenesis of lung fibrosis through regulating TERT transcription in AECs. pens knights highlights

KLF4 defines the efficacy of the epidermal growth factor receptor ...

KLF4 Gene - GeneCards KLF4 Protein KLF4 Antibody

WebJun 7, 2024 · Figure 1. Dynamic KLF4 binding during reprogramming and association with chromatin accessibility and enhancer activity. a Schematic illustration of the experimental system and strategy.b Tornado plots of KLF4 ChIP-seq signals at different reprogramming stages clustered in four different categories: Early, Mid, Late and Transient KLF4 binding. … WebNational Center for Biotechnology Information pens knee protocolWebAntibodies that detect KLF4 can be used in several scientific applications, including Western Blot, Immunocytochemistry, Immunohistochemistry, ELISA and Immunoprecipitation. … penske wicomico

"WebOn the basis of in vivo KLF4 chromatin immunoprecipitation-sequencing (ChIP-seq) analyses and studies of cholesterol-treated cultured SMCs, we identified >800 KLF4 target … " - Klf4 chip

Klf4 chip

Structurally-discovered KLF4 variants accelerate and stabilize ...

WebJun 13, 2011 · KLF4 is essential for IL-4–mediated macrophage M2 polarization. ( A) Impairment of M2 marker gene expression in KLF4-deficient macrophages. PMs isolated from Mye-WT and Mye-KO mice were treated with IL-4 for 16 hours. n = 3 in each group. ( B) KLF4 overexpression enhances M2 gene expression. WebSee all KLF4 primary antibodies Description Rabbit polyclonal to KLF4 Host species Rabbit Specificity ab106629 will detect all three known isoforms. It does not cross-react with …

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WebApr 25, 2024 · KLF4 and TFAP2C were previously shown to activate enhancers specific to naïve hESCs 14, 48. In contrast, primed-specific OCT4/BAF-bound enhancers (C6) were enriched in motifs associated with... WebDec 3, 2024 · Both KLF4 and Sp5 have been shown to regulate naive pluripotency in part through the transcriptional regulation of Nanog, whose downregulation marks the exit of ESCs from the naive state into a state that is primed for lineage specification 29 – 31. Interestingly, we observed downregulation of both Nanog and Klf4 in I-BRD9-treated ESCs …

WebSep 27, 2024 · Klf4 reduces stemness phenotype, triggers mesenchymal-epithelial transition (MET)-like molecular changes, and prevents tumor progression in nasopharygeal carcinoma Oncotarget. 2024 Sep 27;8 (55):93924-93941. doi: 10.18632/oncotarget.21370. eCollection 2024 Nov 7. Authors Webklf4-esc.chr17.2m.sam oct4-esc.chr17.2m.sam sox2-esc.chr17.2m.sam These files are originally from the following study investigating the roles that reprogramming factors play when transforming MEF (fibroblasts) into embryonic stem cells. Chronis et al. Cooperative Binding of Transcription Factors Orchestrates Reprogramming

WebOct 14, 2024 · KLF4 was reported as a critical transcription factor (TF) in maintaining endothelial cell homeostasis. As a key transcriptional co-activator, MED1 binds to KLF4 to regulate cell proliferation, differentiation, and apoptosis, as well as somatic cell reprogramming. WebJan 21, 2024 · For KLF4 ChIP, 5 μg of anti-human KLF4 antibody (goat, R&D systems, AF3640) were used. Finally, DNA fragments were purified using Chromatin IP DNA …

WebFeb 17, 2024 · Kruppel-like factor 4 (KLF4) is a zinc finger-containing transcription factor predominantly expressed in terminally differentiated epithelial tissues. Many studies have …

WebAnti-KLF4, Cat. No. ABE2860, is a highly specific rabbit polyclonal antibody that targets Krueppel-like factor 4 (Klf4) and has been tested for use in ChIP-seq, Chromatin Immunoprecipitation (ChIP), Immunoprecipitation, and Western Blotting. - Find MSDS or SDS, a COA, data sheets and more information. today\u0027s guest on glenn beck radioWebApr 10, 2024 · 然而，在老化的组织中，这种允许去分化和再分化的可塑性能力降低，这一缺陷可以通过转录因子oct4、sox2、klf4和myc（oskm）的瞬时转基因表达将成体细胞转化为胚胎多能细胞（称为诱导多能干细胞或ipscs）来修复，并提高受损老化组织的修复能力，如 … today\u0027s guest on desert island discsKLF4 interacts with the SWI/SNF nucleosome remodeling complex to increase chromatin accessibility Having established that loss of KLF reduces chromatin accessibility, we next sought to identify a... pens/knowho hemel hempstead gbWebDec 7, 2024 · In combination with KLF4-ChIP seq data, we observed KLF4 binding enrichment at transcription start sites (TSSs) of more than 50% of genes that were significantly changed in NPCs compared with ESCs (fold-change ≥ 2 or ≤–2, P < 0.05) (Figure 1A), as well as at about 80% of gene bodies (Figure 1A), suggesting a possible KLF4 … today\u0027s guest on drew barrymore showWebTaken together, our results lead us to propose a model where elevated KLF4 levels sustains the oncogenic state of HNSCC by reactivating repressed chromatin domains at key … today\u0027s guest on the view tv showWebKLF4 belongs to the Kruppel-like factor (KLF) family, a group of conserved zinc finger TFs that regulates essential biological processes such as proliferation and development. Reflecting pioneer factor activity, KLF4 uses two out of its three zinc fingers to target a GC-rich hexameric motif enriched within nucleosomal targets22 ( Fig. 7.2 C). today\u0027s guests on fox business channelWebAug 30, 2007 · KLF4 induces a monocytic phenotype in HL-60 cells To determine whether KLF4 participates directly in monocytic differentiation, we retrovirally infected HL-60 cells with either full-length KLF4 or an empty virus control (EV) and analyzed the cells for various myeloid markers 4 days later. today\u0027s gymnastic results