2024 Shoc2 and cancer

Shoc2 and cancer

Author: troy

August undefined, 2024

Web26 Oct 2024 · The potential SHOC2 inhibitor celastrol phenocopied SHOC2 depletion. In addition, we confirmed that SHOC2 expression levels were important for the sensitivity to EGFR-TKIs in vivo . Furthermore, IHC showed the accumulation of cancer cells that express high levels of SHOC2 in lung cancer tissues obtained from patients with NSCLC who … Web13 Jul 2024 · The SHOC2-MRAS-PP1C complex is made up of three proteins that regulate the RAS signaling pathway and help cancer cells with RAS mutations survive. Some of the …

The FBXW7-SHOC2-Raptor Axis Controls the Cross-Talks

WebSulahian, Kwon, and Walsh et al. performed several loss-of-function CRISPR-Cas9 screens in KRAS-mutant cancer cells treated with a MEK inhibitor and define the landscape of modifiers of MEK inhibitor sensitivity while highlighting that SHOC2 is a potent synthetic lethal target that serves as a critical signaling node to mediate MAP kinase pathway … Web11 Oct 2024 · Drug resistance continues to be a major problem associated with cancer treatment. One of the primary causes of anticancer drug resistance is the frequently mutated RAS gene. In particular, considerable efforts have been made to treat KRAS-induced cancers by directly and indirectly controlling the activity of KRAS. However, the RAS protein is still … menthe mulot

lncRNA MALAT1 regulates the resistance of breast cancer cells to ...

WebIt affects around one in 1,000 to 2,500 individuals. Patients with Noonan Syndrome have an increased risk of developing several cancers that affect the blood (leukemia), nervous … Web12 Mar 2024 · Furthermore, SHOC2 selectively binds to Raptor to competitively inhibit the Raptor-mTOR binding to inactivate mTORC1 and induce autophagy, whereas Raptor binding of SHOC2 inhibits the SHOC2-RAS binding to block the MAPK pathway and proliferation. Finally, SHOC2 is overexpressed in pancreatic cancer, which correlated with poor patient … Web15 Jul 2024 · The SHOC2-MRAS-PP1C (“SMP”) complex, a three-protein assembly, regulates the RAS signaling pathway and aids cancer cells with RAS mutations in survival. The high-resolution structure of this complex, revealed by X-ray crystallography and cryogenic electron microscopy , suggests potential drug binding sites for inhibiting the RAS pathway … menthe mythologie

Anti SHOC2 pAb [Catalog No.: ATL-HPA048134]

A Novel Protein Structure

Webwithin the Shoc2 macromolecular complex, post-trans-lational modiﬁcation, and speciﬁc examples of how the Shoc2 scaffold regulates cellular signaling are discussed in the following sections. Thus far, the best-studied role of Shoc2 is in modu-lating signals of the extracellular signal-regulated kinase 1/2 (ERK1/2) pathway. Shoc2 tethers RAS and WebSHOC2 is essential for the proliferation and survival of several cancers including RAS-driven leukaemia; melanoma; and models of non-small cell lung cancer 9,10 . Moreover, … menthene boiling pointWebExplore 30 research articles published by the author Alma L. Burlingame from University of California, San Francisco in the year 2013. The author has contributed to research in topic(s): Mass spectrometry & Phosphorylation. The author has an hindex of 107, co-authored 610 publication(s) receiving 43486 citation(s). Previous affiliations of Alma L. … menthe noire

"Web13 Apr 2024 · Autism spectrum disorder (ASD) is a neurological developmental disorder that affects brain development and function. This affects how people learn, behave, communicate and interact with others, leading to challenges at home, school or work. " - Shoc2 and cancer

Shoc2 and cancer

WebThe Molecular Glue Degrader Landscape in 2024 Web1 Feb 2024 · The structural features of SHOC2 that mediate its known functions are reviewed, discussed in the context of various binding partners and signaling pathways, and areas of SH OC2 biology where a consensus view has not yet emerged are highlighted. SHOC2 is a prototypical leucine-rich repeat protein that promotes downstream receptor …

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WebThese observations explain how mutant versions of SHOC2 in RASopathies and cancer stabilize the interactions of complex members to enhance holophosphatase activity. Together, this integrative structure-function model comprehensively defines key binding interactions within the SHOC2-MRAS-PP1C holophosphatase complex and will inform … Web10 Jun 2024 · This study highlights a critical role for SHOC2 as part of the MRAS-SHOC2-PP1 phosphatase complex for oncogenic ERK signalling in NSCLC, the leading cause of …

Web4 Feb 2024 · SHOC2 acts as a strong synthetic lethal interactor with MEK inhibitors in multiple KRAS cancer cell lines. SHOC2 forms a heterotrimeric complex with MRAS and PP1C that is essential for regulating RAF and MAPK-pathway activation by dephosphorylating a specific phosphoserine on RAF kinases ... Macromolecules Web26 Nov 2024 · Happy to share our latest work on the SHOC2-MRAS-PP1C (SMP) complex which is now published online in Nature Structural and Molecular Biology. ... (NAD) mapping in twelve human cell lines (Cancer ...

Web13 Jul 2024 · Interestingly, we found significant co-dependencies of SHOC2 and canonical RAS proteins in cancer cells expressing oncogenic RAS with GTP-activating mutations but … Web29 Jun 2024 · SHOC2 is as an essential scaffolding protein that engages both PP1C and RAS to dephosphorylate RAF NTpS11–13, but the structure of SHOC2 and the …

Web24 Nov 2024 · Aim: To explore the roles of lncRNA MALAT1 and SHOC2 in breast cancer, and the potential connections to chemotherapy resistance in breast cancer. Materials & methods: Paclitaxel-resistant breast cancer cells were induced by gradually increasing intermittent doses. Bioinformatic analyses were performed to predict the regulated …

WebView SHOC2 mouse/human homology from Alliance Direct with: genes, location, sequences, associated human diseases menthe nanahWebMolecular Cell Article An MRAS, SHOC2, and SCRIB Complex Coordinates ERK Pathway Activation with Polarity and Tumorigenic Growth Lucy C. Young,1 Nicole Hartig,1,6 Marta Mun˜oz-Alegre,1,6 Juan A. Oses-Prieto,2 Sevi Durdu,3 Sabine Bender,1 Vineetha Vijayakumar,4 Matteo Vietri Rudan, 1Christina Gewinner, 1Stephen Henderson, Amit P. … menthe nanaWebthe interest in these proteins primarily because of the central role that this cascade plays in cancer development. The important role of Raf in cancer ... scaffolding protein Sur-8/SHOC2.48 A complex between Sur-8/SHOC2 and the catalytic subunit of PP1c is an effector of the Ras family protein M-Ras, which can dephosphorylate ... menthe nepetaWeb24 Jun 2024 · Original Article Jun 24, 2024. Acquired Resistance to KRASG12C Inhibition in Cancer. M. M. Awad and Others. A study involving 38 patients who initially had a response to adagrasib or who had a ... menthe nom latinWebNational Center for Biotechnology Information menthe nom en latinWebSHOC2 is associated with the survival of breast cancer cells and has prognostic value for patients with breast cancer. SHOC2 leucine rich repeat scaffold protein (SHOC2) has … menthe non comestibleWeb4 May 2024 · SHOC2 inhibition lowers the concentration of MEK inhibitor required for cytotoxicity and drives tumor regressions in xenograft models. Biochemically, we show … men the north face