WebTOX3 expression is highly up-regulated in luminal subtype tumors compared to normal breast tissues or basal-like tumors. Expression quantitative trait loci (eQTL) analyses … WebTOX3 is a newly identified gene that has been observed to correlate with breast cancer by genome-wide association studies (GWAS) in recent years. In addition, it has been noted that single-nucleotide polymorphisms (SNPs) in the TOX3 gene have a strong correlation with estrogen receptor (ER)-positive …

TOX3 regulates neural progenitor identity - PubMed

WebMar 14, 2024 · TOX3 gene localizes on chromosome 16q12.1; it has seven exons and encodes the nuclear protein TOX3. TOX3 induces transcription of estrogens and Bcl-2-sensitive promoters, and binds to a BRCA1 promoter region to downregulate its expression through methylation [ 13, 14, 15 ]. WebJan 11, 2013 · By database searching for the human homolog of mouse Tox3, O'Flaherty and Kaye (2003) identified TOX3, which they called TNRC9. The deduced 576-amino acid protein has a calculated molecular mass of 63.3 kD. It has a central lysine-rich nuclear localization signal followed by an HMG box. mhealth fairview eagan clinic

ToxTutor Has a New Home. NLM Technical Bulletin. 2024 May–Jun

WebJan 30, 2015 · We found TOX3 expression in estrogen receptor-positive mammary epithelial cells, including progenitor cells. A subset of breast tumors also highly expresses TOX3, with poor outcome associated with high expression of TOX3 in luminal B breast cancers. WebAug 24, 2024 · Traditionally, TOX3 comes with a kit that includes an HDMI cable, power supply, instructions and a simple IR remote control. The new TOX3 TV Box with AMlogic … WebWe found Tox3 to be predominantly expressed in the developing mouse brain with a peak at embryonic day E14 where it co-localizes with the neural stem and progenitor markers Nestin and Sox2 in radial glia of the ventricular zone and intermediate progenitors of the subventricular zone. m health fairview eden prairie mn